Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine
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چکیده
منابع مشابه
Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease.
The present study was undertaken to investigate the neuroprotective effects of resveratrol (RES) on 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD) in rats. PD is an age-related neurodegenerative disorder in which the role of reactive oxygen species (ROS) is strongly implicated. RES, a polyphenolic antioxidant compound enriched in grapes, has been shown to have antioxidant and anti-...
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Performance maintained by differential-reinforcement-of-low-rate operant schedules has been found to be sensitive to antidepressant drugs. Tricyclic antidepressants, monoamine oxidase inhibitors and atypical antidepressants reduce response rate and increase reinforcement rate under long differential-reinforcement-of-low-rate schedules. In order to study the neurochemical mechanism by which the ...
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The effects on food intake of repeated administration of d-amphetamine and fenfluramine were examined in rats adapted to a 4 hr/day feeding schedule. Control rats given daily injections of amphetamine before food access rapidly developed a partial tolerance to the food intake reducing effect of amphetamine. However, rats given a 6-hydroxydopamine (6-HDA) treatment which produced a large selecti...
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the former perspective, mean gluten effects on individual parameters could not be considered as "independent" observations, both because schizophrenia is clinically heterogenous and because in performing the ratings each dimension has to be regarded as separate and independent. It is certainly unlikely that the arguable relatedness of parameters could account for the probability of I in 10,000 ...
متن کاملEffects of amphetamine derivatives on brain dopamine and noradrenaline.
1. Intracisternally administered metaraminol, alpha-methyl-octopamine, alpha-methyl-m-tyramine, and alpha-methyl tyramine were found to lower brain noradrenaline without having an effect on brain dopamine.2. Amphetamine, mephentermine, and norephedrine had no effect on brain catecholamines after intracisternal injection.3. There was no reduction in brain dopamine content after intracisternal in...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1971
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1971.tb07089.x